| Gene Information | |
|---|---|
| Gene Name | CBX4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 560 |
| Protein Names | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000141582 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00257 |
| Gene Card | CBX4 |
| Uniprot ID | O00257 |
| Pfam | PF17218; PF00385 |
| In ASD | no |
| Allosteric Prediction | yes (0.474675647) |
| Ortholog in Animals | Alpaca_ CBX4 ( ortholog_one2one ) Dog_ CBX4 ( ortholog_one2one ) GuineaPig_ CBX4 ( ortholog_one2one ) Macaque_ CBX4 ( ortholog_one2one ) Mouse_ Cbx4 ( ortholog_one2one ) Pig_ CBX4 ( ortholog_one2one ) Rat_ Cbx4 ( ortholog_one2one ) Rabbit_ CBX4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CBX6, NPTXR, CBX1, CBX3, CBX7, CBX2, CBX5, CBX8 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.052648(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K28 (NMR - ) 3I8Z (X-ray 1.51A ) 5EPL (X-ray 1.81A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12679040, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:19266028}. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235). {ECO:0000269|PubMed:18927235, ECO:0000269|PubMed:22467880}. |
| Mouse PG classification | NA |
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