| Gene Information | |
|---|---|
| Gene Name | TXNRD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 649 |
| Protein Names | Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) |
| Target Name | cytoplasmic thioredoxin reductase |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000198431 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | NA |
| Gene Card | TXNRD1 |
| Uniprot ID | Q16881 |
| Pfam | PF00462; PF07992; PF02852 |
| In ASD | no |
| Allosteric Prediction | yes (0.69427687) |
| Ortholog in Animals | Alpaca_ TXNRD1 ( ortholog_one2one ) Dog_ TXNRD1 ( ortholog_one2one ) GuineaPig_ TXNRD1 ( ortholog_one2one ) Macaque_ TXNRD1 ( ortholog_one2one ) Mouse_ Txnrd1 ( ortholog_one2one ) Pig_ TXNRD1 ( ortholog_one2one ) Rat_ Txnrd1 ( ortholog_one2one ) Rabbit_ TXNRD1 ( ortholog_one2one ) |
| Ohnologs | TXNRD3 |
| Paralogs | TXNRD3, AIFM3, AIFM1, PYROXD1, DLD, TXNRD2, GSR |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. {ECO:0000269|PubMed:18042542}.; [Isoform 4]: Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. {ECO:0000269|PubMed:8999974}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CFY (X-ray 2.70A ) 2J3N (X-ray 2.80A ) 2ZZ0 (X-ray 2.80A ) 2ZZB (X-ray 3.20A ) 2ZZC (X-ray 2.60A ) 3QFA (X-ray 2.20A ) 3QFB (X-ray 2.60A ) |
| DBSNP | rs1127954 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18042542}.; [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:15199063}. Nucleus {ECO:0000269|PubMed:15199063}.; [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15199063}. |
| Mouse PG classification | NA |
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