| Gene Information | |
|---|---|
| Gene Name | CBR3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000159231 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75828 |
| Gene Card | CBR3 |
| Uniprot ID | O75828 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | no (-0.132267314) |
| Ortholog in Animals | Alpaca_ CBR3 ( ortholog_one2one ) Dog_ CBR3 ( ortholog_one2one ) GuineaPig_ CBR3 ( ortholog_one2one ) Macaque_ CBR1 ( ortholog_one2one ) Mouse_ Cbr3 ( ortholog_one2one ) Pig_ CBR3 ( ortholog_one2one ) Rat_ Cbr3 ( ortholog_one2one ) Rabbit_ CBR3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DHRS7C, DHRS7, HSD11B1, RDH8, HSDL2, DHRS7B, DHRS2, HSD11B1L, DHRS4L2, DHRS4, DHRS11, CBR1, DHRS1 |
| Tissue | NA |
| Tissue Specificity | Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. {ECO:0000269|PubMed:18493841}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HRB (X-ray 1.90A ) |
| DBSNP | rs8133052 rs9282628 rs2835285 rs16993929 rs4987121 rs1056892 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18493841}. |
| Mouse PG classification | NA |
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