| Gene Information | |
|---|---|
| Gene Name | CBR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) |
| Target Name | s-nitrosoglutathione reductase |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000159228 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P16152 |
| Gene Card | CBR1 |
| Uniprot ID | P16152 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | yes (0.554114501) |
| Ortholog in Animals | Alpaca_ CBR1 ( ortholog_one2one ) Dog_ CBR1 ( ortholog_one2one ) Mouse_ Gm5678 ( ortholog_one2many ) Mouse_ Cbr1 ( ortholog_one2many ) Pig_ CBR1 ( ortholog_one2many ) Rat_ Cbr1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | DHRS7C, DHRS7, HSD11B1, RDH8, CBR3, HSDL2, DHRS7B, DHRS2, HSD11B1L, DHRS4L2, DHRS4, DHRS11, DHRS1 |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney (at protein level). {ECO:0000269|PubMed:1597188}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WMA (X-ray 1.24A ) 2PFG (X-ray 1.54A ) 3BHI (X-ray 2.27A ) 3BHJ (X-ray 1.77A ) 3BHM (X-ray 1.80A ) 4Z3D (X-ray 1.80A ) |
| DBSNP | rs1143663 rs41557318 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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