| Gene Information | |
|---|---|
| Gene Name | DLG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 724 |
| Protein Names | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) |
| Target Name | disks large homolog 4 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000132535 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P78352 |
| Gene Card | DLG4 |
| Uniprot ID | P78352 |
| Pfam | PF00625; PF10608; PF00595; PF10600; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.423331681) |
| Ortholog in Animals | Alpaca_ DLG4 ( ortholog_one2one ) Dog_ DLG4 ( ortholog_one2one ) GuineaPig_ DLG4 ( ortholog_one2one ) Macaque_ DLG4 ( ortholog_one2one ) Mouse_ Dlg4 ( ortholog_one2one ) Pig_ DLG4 ( ortholog_one2one ) Rat_ Dlg4 ( ortholog_one2one ) Rabbit_ DLG4 ( ortholog_one2one ) |
| Ohnologs | DLG3, DLG1, DLG2 |
| Paralogs | DLG1, DLG3, DLG2 |
| Tissue | NA |
| Tissue Specificity | Brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KEF (NMR - ) 2MES (NMR - ) 3I4W (X-ray 1.35A ) 3K82 (X-ray 1.40A ) 3ZRT (X-ray 3.40A ) 5J7J (NMR - ) 5JXB (X-ray 2.90A ) 6QJD (X-ray 1.55A ) 6QJF (X-ray 1.50A ) 6QJG (X-ray 2.00A ) 6QJI (X-ray 1.50A ) 6QJJ (X-ray 1.70A ) 6QJK (X-ray 1.05A ) 6QJL (X-ray 1.04A ) 6QJN (X-ray 1.80A ) 6SPV (X-ray 2.04A ) 6SPZ (X-ray 2.08A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12151521}; Lipid-anchor {ECO:0000269|PubMed:12151521}; Cytoplasmic side {ECO:0000269|PubMed:12151521}. Postsynaptic density {ECO:0000250|UniProtKB:P31016}. Synapse {ECO:0000269|PubMed:12151521}. Cytoplasm {ECO:0000250|UniProtKB:P31016}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P31016}. Cell projection, dendrite {ECO:0000250|UniProtKB:P31016}. Presynapse {ECO:0000250|UniProtKB:P31016}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. {ECO:0000250|UniProtKB:P31016}. |
| Mouse PG classification | NA |
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