| Gene Information | |
|---|---|
| Gene Name | SSRP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 709 |
| Protein Names | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) |
| Target Name | facilitates chromatin transcription complex |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000149136 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q08945 |
| Gene Card | SSRP1 |
| Uniprot ID | Q08945 |
| Pfam | PF00505; PF17292; PF08512; PF03531 |
| In ASD | no |
| Allosteric Prediction | yes (0.266347029) |
| Ortholog in Animals | Alpaca_ SSRP1 ( ortholog_one2one ) Dog_ SSRP1 ( ortholog_one2one ) GuineaPig_ SSRP1 ( ortholog_one2one ) Macaque_ SSRP1 ( ortholog_one2one ) Mouse_ Ssrp1 ( ortholog_one2one ) Pig_ SSRP1 ( ortholog_one2one ) Rat_ Ssrp1 ( ortholog_one2one ) Rabbit_ SSRP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SP140, HMGB2, UBTF, TOX4, UBTFL1, HMGB1P1, HMGB1, SP100, SMARCE1, HMGB3, HMG20A, TFAM, HMG20B, TOX2, TOX, SP110, HMGB4, SP140L, HMGXB4, TOX3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001546(Rat);0.035873(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4IFS (X-ray 1.93A ) 5UMR (X-ray 1.50A ) 5UMS (X-ray 1.57A ) 5VWE (NMR - ) 6L1E (X-ray 2.09A ) 6L1R (X-ray 1.80A ) 6L34 (X-ray 2.00A ) 6UPK (EM 4.90A ) 6UPL (EM 7.40A ) |
| DBSNP | rs768436 rs11540304 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10421373, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. {ECO:0000250|UniProtKB:Q05344}. |
| Mouse PG classification | NA |
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