| Gene Information | |
|---|---|
| Gene Name | PCBP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 356 |
| Protein Names | Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 101 ( ENSG00000169564 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15365 |
| Gene Card | PCBP1 |
| Uniprot ID | Q15365 |
| Pfam | PF00013 |
| In ASD | no |
| Allosteric Prediction | no (-0.422983559) |
| Ortholog in Animals | Alpaca_ PCBP1 ( ortholog_one2one ) Dog_ PCBP1 ( ortholog_one2one ) GuineaPig_ PCBP1 ( ortholog_one2one ) Macaque_ PCBP1 ( ortholog_one2one ) Mouse_ Pcbp1 ( ortholog_one2one ) Pig_ PCBP1 ( ortholog_one2one ) Rat_ Pcbp1 ( ortholog_one2one ) Rabbit_ PCBP1 ( ortholog_one2one ) |
| Ohnologs | PCBP4 |
| Paralogs | HNRNPK, NOVA2, FUBP3, FUBP1, IGF2BP1, KHSRP, PCBP4, PCBP3, IGF2BP3, IGF2BP2, NOVA1, PCBP2 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands. {ECO:0000269|PubMed:7607214, ECO:0000269|PubMed:8152927}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WVN (X-ray 2.10A ) 1ZTG (X-ray 3.00A ) 3VKE (X-ray 1.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:7607214}. Cytoplasm {ECO:0000269|PubMed:7607214}. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214). {ECO:0000269|PubMed:7607214}. |
| Mouse PG classification | NA |
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