| Gene Information | |
|---|---|
| Gene Name | CAST |
| Organism | Homo sapiens (Human) |
| Gene Length | 510 |
| Protein Names | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (DNA-directed RNA polymerase I subunit G) (RNA polymerase I-associated factor PAF49) |
| Target Name | calpastatin |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000153113 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O15446 |
| Gene Card | POLR1G |
| Uniprot ID | O15446 |
| Pfam | PF08208 |
| In ASD | no |
| Allosteric Prediction | yes (0.331807399) |
| Ortholog in Animals | Alpaca_ CAST ( ortholog_one2one ) Dog_ CAST ( ortholog_one2one ) Macaque_ CAST ( ortholog_one2one ) Mouse_ Cast ( ortholog_one2one ) Pig_ CAST ( ortholog_one2one ) Rat_ Cast ( ortholog_one2one ) Rabbit_ CAST ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7OB9 (EM 2.70A ) 7OBA (EM 3.10A ) 7OBB (EM 3.30A ) 7VBA (EM 2.89A ) 7VBB (EM 2.81A ) 7VBC (EM 3.01A ) 8A43 (EM 4.09A ) |
| DBSNP | rs735482 rs3212989 rs762562 rs2336219 rs3212986 rs3212986 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:9426281}. Chromosome {ECO:0000269|PubMed:9426281}. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes. |
| Mouse PG classification | HPG |
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