Gene Information
Gene NameCASR
OrganismHomo sapiens (Human)
Gene Length1078
Protein NamesExtracellular calcium-sensing receptor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1)
Target Nameextracellular calcium-sensing receptor
Target TypeSuccessful target
Gene Age680 ( ENSG00000036828 )
Evolutionary StageEumetazoa
AlphaFoldDBP41180
Gene CardCASR
Uniprot IDP41180
PfamPF00003; PF01094; PF07562
In ASDyes
Allosteric Predictionyes (1.476120821)
Ortholog in AnimalsAlpaca_ CASR ( ortholog_one2one )
Dog_ CASR ( ortholog_one2one )
GuineaPig_ CASR ( ortholog_one2one )
Macaque_ CASR ( ortholog_one2one )
Mouse_ Casr ( ortholog_one2one )
Pig_ CASR ( ortholog_one2one )
Rat_ Casr ( ortholog_one2one )
Rabbit_ CASR ( ortholog_one2one )
OhnologsGPRC6A
ParalogsTAS1R3, TAS1R1, TAS1R2, GPRC6A
Tissuekidney
Tissue SpecificityExpressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. {ECO:0000269|PubMed:18756473}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004990(Rat);0.080000(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5FBH  (X-ray  2.70A  )  5FBK  (X-ray  2.10A  )  5K5S  (X-ray  2.60A  )  5K5T  (X-ray  3.10A  )  7DTT  (EM  3.80A  )  7DTU  (EM  4.40A  )  7DTV  (EM  3.50A  )  7DTW  (EM  4.50A  )  7E6T  (EM  3.00A  )  7E6U  (EM  6.00A  )  7M3E  (EM  3.20A  )  7M3F  (EM  2.80A  )  7M3G  (EM  2.50A  )  7M3J  (EM  4.10A  )  7SIL  (EM  2.70A  )  7SIM  (EM  2.70A  )  7SIN  (EM  5.90A  ) 
DBSNP rs200673016  rs104893717  rs199515839  rs1064794290  rs121909262  rs1553765909  rs104893702  rs886041154  rs121909265  rs121909266  rs1276839362  rs104893691  rs104893695  rs104893708  rs121909260  rs104893696  rs121909267  rs121909263  rs121909264  rs769256610  rs104893694  rs193922441  rs201851934  rs1060502855  rs121909268  rs104893689  rs104893697  rs1482119762  rs397514728  rs397514728  rs28936684  rs28936684  rs62269092  rs121909259  rs1064794291  rs104893716  rs193922423  rs1060502861  rs104893719  rs777646067  rs104893690  rs104893690  rs104893712  rs104893698  rs104893703  rs104893700  rs773146939  rs121909261  rs753013993  rs104893718  rs104893699  rs104893701  rs104893711  rs121909258  rs140022350  rs104893693  rs1057518933  rs104893710  rs104893706  rs200777304  rs104893704  rs121909269  rs4987051  rs200620134  rs1801725  rs759027000  rs1042636  rs1801726 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:15572418, ECO:0000269|PubMed:16740594, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:20861236, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:8702647};
Multi-pass membrane protein {ECO:0000269|PubMed:20861236}.
Mouse PG classificationHPG
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