Gene Information
Gene NameSCN2B
OrganismHomo sapiens (Human)
Gene Length215
Protein NamesSodium channel subunit beta-2
Target Namesodium channel subunit beta-2
Target TypeNA
Gene Age680 ( ENSG00000149575 )
Evolutionary StageVertebrata
AlphaFoldDBO60939
Gene CardSCN2B
Uniprot IDO60939
PfamPF07686
In ASDno
Allosteric Predictionyes (0.145457788)
Ortholog in AnimalsAlpaca_ SCN2B ( ortholog_one2one )
Dog_ SCN2B ( ortholog_one2one )
GuineaPig_ SCN2B ( ortholog_one2one )
Macaque_ SCN2B ( ortholog_one2one )
Mouse_ Scn2b ( ortholog_one2one )
Pig_ SCN2B ( ortholog_one2one )
Rat_ Scn2b ( ortholog_one2one )
Rabbit_ SCN2B ( ortholog_one2one )
OhnologsNA
ParalogsSCN4B, MPZL1, JAML, MPZ, MPZL3, MPZL2
Tissuebrain, cerebral.cortex, cerebellar.hemisphere, cerebellum, nucleus.accumbens
Tissue SpecificityBrain specific.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5FDY  (X-ray  1.85A  )  5FEB  (X-ray  1.35A  )  6J8E  (EM  3.00A  )  6J8G  (EM  3.20A  )  6J8H  (EM  3.20A  )  6J8I  (EM  3.20A  )  6J8J  (EM  3.20A  )  6VRR  (X-ray  1.45A  )  7W77  (EM  3.30A  )  7W7F  (EM  3.35A  )  7W9K  (EM  2.20A  )  7W9L  (EM  3.50A  )  7W9M  (EM  3.00A  )  7W9P  (EM  2.90A  )  7W9T  (EM  3.00A  )  7XVE  (EM  2.70A  )  7XVF  (EM  2.80A  ) 
DBSNP rs72544145  rs17121819  rs17121818  rs587777023 
Subcellular location [CC]Membrane;
Single-pass type I membrane protein.
Mouse PG classificationLPG
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