| Gene Information | |
|---|---|
| Gene Name | CASP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] |
| Target Name | caspase-4 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000196954 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P49662 |
| Gene Card | CASP4 |
| Uniprot ID | P49662 |
| Pfam | PF00619 |
| In ASD | no |
| Allosteric Prediction | yes (0.212199231) |
| Ortholog in Animals | Alpaca_ CASP4 ( ortholog_one2one ) Macaque_ CASP4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PYCARD, CASP14, CASP8, CASP2, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP3, CASP7, PYDC1, CASP12, CASP5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, including in keratinocytes and colonic and small intestinal epithelial cells (at protein level). Not detected in brain. {ECO:0000269|PubMed:10986288, ECO:0000269|PubMed:22246630, ECO:0000269|PubMed:25121752, ECO:0000269|PubMed:7743998, ECO:0000269|PubMed:7797510, ECO:0000269|PubMed:7797592}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6KMZ (X-ray 3.61A ) 6NRY (X-ray 2.18A ) |
| DBSNP | rs56226603 rs181090259 rs55901059 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:23661706}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:23661706}; Peripheral membrane protein {ECO:0000269|PubMed:23661706}; Cytoplasmic side {ECO:0000269|PubMed:23661706}. Mitochondrion {ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:23661706}. Inflammasome {ECO:0000269|PubMed:25119034, ECO:0000269|PubMed:26508369}. Secreted {ECO:0000269|PubMed:22246630}. Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214 (PubMed:15123740). Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630). {ECO:0000269|PubMed:15123740, ECO:0000269|PubMed:22246630}. |
| Mouse PG classification | NA |
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