| Gene Information | |
|---|---|
| Gene Name | CASP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] |
| Target Name | caspase-3 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000164305 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P42574 |
| Gene Card | CASP3 |
| Uniprot ID | P42574 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | yes (1.398939173) |
| Ortholog in Animals | Alpaca_ CASP3 ( ortholog_one2one ) Dog_ CASP3 ( ortholog_one2one ) Macaque_ CASP3 ( ortholog_one2one ) Mouse_ Casp3 ( ortholog_one2one ) Pig_ CASP3 ( ortholog_one2one ) Rat_ Casp3 ( ortholog_one2one ) Rabbit_ CASP3 ( ortholog_one2one ) |
| Ohnologs | CASP7, CASP6 |
| Paralogs | PYCARD, CASP14, CASP8, CASP2, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP5, CASP4, PYDC1, CASP12, CASP7 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. {ECO:0000269|PubMed:7983002}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.034206(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1CP3 (X-ray 2.30A ) 1GFW (X-ray 2.80A ) 1I3O (X-ray 2.70A ) 1NME (X-ray 1.60A ) 1NMQ (X-ray 2.40A ) 1NMS (X-ray 1.70A ) 1PAU (X-ray 2.50A ) 1QX3 (X-ray 1.90A ) 1RE1 (X-ray 2.50A ) 1RHJ (X-ray 2.20A ) 1RHK (X-ray 2.50A ) 1RHM (X-ray 2.50A ) 1RHQ (X-ray 3.00A ) 1RHR (X-ray 3.00A ) 1RHU (X-ray 2.51A ) 2C1E (X-ray 1.77A ) 2C2K (X-ray 1.87A ) 2C2M (X-ray 1.94A ) 2C2O (X-ray 2.45A ) 2CDR (X-ray 1.70A ) 2CJX (X-ray 1.70A ) 2CJY (X-ray 1.67A ) 2CNK (X-ray 1.75A ) 2CNL (X-ray 1.67A ) 2CNN (X-ray 1.70A ) 2CNO (X-ray 1.95A ) 2DKO (X-ray 1.06A ) 2H5I (X-ray 1.69A ) 2H5J (X-ray 2.00A ) 2H65 (X-ray 2.30A ) 2J30 (X-ray 1.40A ) 2J31 (X-ray 1.50A ) 2J32 (X-ray 1.30A ) 2J33 (X-ray 2.00A ) 2XYG (X-ray 1.54A ) 2XYH (X-ray 1.89A ) 2XYP (X-ray 1.86A ) 2XZD (X-ray 2.10A ) 2XZT (X-ray 2.70A ) 2Y0B (X-ray 2.10A ) 3DEH (X-ray 2.50A ) 3DEI (X-ray 2.80A ) 3DEJ (X-ray 2.60A ) 3DEK (X-ray 2.40A ) 3EDQ (X-ray 1.61A ) 3GJQ (X-ray 2.60A ) 3GJR (X-ray 2.20A ) 3GJS (X-ray 1.90A ) 3GJT (X-ray 2.20A ) 3H0E (X-ray 2.00A ) 3ITN (X-ray 1.63A ) 3KJF (X-ray 2.00A ) 3PCX (X-ray 1.50A ) 3PD0 (X-ray 2.00A ) 3PD1 (X-ray 1.62A ) 4DCJ (X-ray 1.70A ) 4DCO (X-ray 1.70A ) 4DCP (X-ray 1.70A ) 4EHA (X-ray 1.70A ) 4EHD (X-ray 1.58A ) 4EHF (X-ray 1.66A ) 4EHH (X-ray 1.78A ) 4EHK (X-ray 1.67A ) 4EHL (X-ray 1.80A ) 4EHN (X-ray 1.69A ) 4JJE (X-ray 1.48A ) 4JQY (X-ray 2.50A ) 4JQZ (X-ray 2.89A ) 4JR0 (X-ray 1.80A ) 4PRY (X-ray 1.70A ) 4PS0 (X-ray 1.63A ) 4QTX (X-ray 1.97A ) 4QTY (X-ray 1.60A ) 4QU0 (X-ray 1.95A ) 4QU5 (X-ray 1.91A ) 4QU8 (X-ray 1.72A ) 4QU9 (X-ray 1.56A ) 4QUA (X-ray 1.89A ) 4QUB (X-ray 1.69A ) 4QUD (X-ray 2.00A ) 4QUE (X-ray 1.84A ) 4QUG (X-ray 1.92A ) 4QUH (X-ray 1.76A ) 4QUI (X-ray 1.76A ) 4QUJ (X-ray 1.50A ) 4QUL (X-ray 1.90A ) 5I9B (X-ray 1.80A ) 5I9T (X-ray 1.95A ) 5IAB (X-ray 1.79A ) 5IAE (X-ray 1.55A ) 5IAG (X-ray 1.98A ) 5IAJ (X-ray 1.58A ) 5IAK (X-ray 1.82A ) 5IAN (X-ray 2.70A ) 5IAR (X-ray 1.76A ) 5IAS (X-ray 1.54A ) 5IBC (X-ray 1.66A ) 5IBP (X-ray 1.38A ) 5IBR (X-ray 1.74A ) 5IC4 (X-ray 2.65A ) |
| DBSNP | rs35578277 rs1049210 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15003516}. |
| Mouse PG classification | NA |
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