| Gene Information | |
|---|---|
| Gene Name | PHLDB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1253 |
| Protein Names | Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000144824 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q86SQ0 |
| Gene Card | PHLDB2 |
| Uniprot ID | Q86SQ0 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.274202094) |
| Ortholog in Animals | Alpaca_ PHLDB2 ( ortholog_one2one ) Dog_ PHLDB2 ( ortholog_one2one ) GuineaPig_ PHLDB2 ( ortholog_one2one ) Macaque_ PHLDB2 ( ortholog_one2one ) Mouse_ Phldb2 ( ortholog_one2one ) Pig_ PHLDB2 ( ortholog_one2one ) Rat_ Phldb2 ( ortholog_one2one ) Rabbit_ PHLDB2 ( ortholog_one2one ) |
| Ohnologs | PHLDB3 |
| Paralogs | GAB3, PHLDB3, GAB1, GAB4, PHLDB1, PLEKHS1, GAB2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3749298 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12376540}. Membrane {ECO:0000269|PubMed:12376540}; Peripheral membrane protein {ECO:0000269|PubMed:12376540}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments. |
| Mouse PG classification | NA |
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