| Gene Information | |
|---|---|
| Gene Name | CASL |
| Organism | Homo sapiens (Human) |
| Gene Length | 834 |
| Protein Names | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q14511 |
| Gene Card | NEDD9 |
| Uniprot ID | Q14511 |
| Pfam | PF12026; PF08824; PF14604 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in B-cells (at protein level) (PubMed:9020138). Expressed in the respiratory epithelium of the main bronchi to the bronchioles in the lungs (at protein level) (PubMed:9584194). High levels detected in kidney, lung, and placenta (PubMed:9584194). Expressed in lymphocytes (PubMed:9497377). {ECO:0000269|PubMed:9020138, ECO:0000269|PubMed:9497377, ECO:0000269|PubMed:9584194}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2L81 (NMR - ) 5X3S (X-ray 2.90A ) |
| DBSNP | rs11546959 rs34184473 rs3734401 |
| Subcellular location [CC] | Cytoplasm, cell cortex {ECO:0000269|PubMed:11827972}. Nucleus {ECO:0000269|PubMed:29899023, ECO:0000269|PubMed:8668148, ECO:0000269|PubMed:9584194}. Golgi apparatus {ECO:0000269|PubMed:8668148}. Cell projection, lamellipodium {ECO:0000269|PubMed:24574519, ECO:0000269|PubMed:8668148}. Cytoplasm {ECO:0000269|PubMed:11827972, ECO:0000269|PubMed:9584194}. Cell junction, focal adhesion {ECO:0000269|PubMed:19103205, ECO:0000269|PubMed:19275884, ECO:0000269|PubMed:29191835, ECO:0000269|PubMed:8668148}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11827972}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16394104, ECO:0000269|PubMed:9584194}. Cell projection, cilium {ECO:0000269|PubMed:17604723}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723}. Basolateral cell membrane {ECO:0000250|UniProtKB:A0A8I3PDQ1}.; [Enhancer of filamentation 1 p55]: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9584194}. |
| Mouse PG classification | NA |
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