| Gene Information | |
|---|---|
| Gene Name | NR1H2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) |
| Target Name | oxysterols receptor lxr-beta |
| Target Type | Clinical trial target |
| Gene Age | 810 ( ENSG00000131408 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P55055 |
| Gene Card | NR1H2 |
| Uniprot ID | P55055 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.00021701) |
| Ortholog in Animals | Alpaca_ NR1H2 ( ortholog_one2one ) Dog_ NR1H2 ( ortholog_one2one ) GuineaPig_ NR1H2 ( ortholog_one2one ) Macaque_ NR1H2 ( ortholog_one2one ) Mouse_ Nr1h2 ( ortholog_one2one ) Pig_ NR1H2 ( ortholog_one2one ) Rat_ Nr1h2 ( ortholog_one2one ) |
| Ohnologs | NR1H3 |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, PPARD, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002569(Rat);0.047059(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1P8D (X-ray 2.80A ) 1PQ6 (X-ray 2.40A ) 1PQ9 (X-ray 2.10A ) 1PQC (X-ray 2.80A ) 1UPV (X-ray 2.10A ) 1UPW (X-ray 2.40A ) 3KFC (X-ray 2.40A ) 3L0E (X-ray 2.30A ) 4DK7 (X-ray 2.45A ) 4DK8 (X-ray 2.75A ) 4NQA (X-ray 3.10A ) 4RAK (X-ray 2.04A ) 5HJP (X-ray 2.60A ) 5I4V (X-ray 2.61A ) 5JY3 (X-ray 2.40A ) 5KYA (X-ray 2.60A ) 5KYJ (X-ray 2.80A ) 6JIO (X-ray 2.60A ) 6K9G (X-ray 2.80A ) 6K9H (X-ray 2.50A ) 6K9M (X-ray 2.90A ) 6S4N (X-ray 1.90A ) 6S4T (X-ray 2.00A ) 6S4U (X-ray 2.81A ) 6S5K (X-ray 1.60A ) |
| DBSNP | rs41379547 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Mouse PG classification | NA |
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