| Gene Information | |
|---|---|
| Gene Name | CARMA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1154 |
| Protein Names | Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BXL7 |
| Gene Card | CARD11 |
| Uniprot ID | Q9BXL7 |
| Pfam | PF00619 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. {ECO:0000269|PubMed:11278692}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4JUP (X-ray 3.20A ) 4LWD (X-ray 1.79A ) |
| DBSNP | rs387907352 rs387907351 rs3735134 rs3735133 rs1064795307 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17287217}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:17287217}. |
| Mouse PG classification | NA |
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