| Gene Information | |
|---|---|
| Gene Name | CAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P78310 |
| Gene Card | CXADR |
| Uniprot ID | P78310 |
| Pfam | PF00047; PF07686 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1EAJ (X-ray 1.35A ) 1F5W (X-ray 1.70A ) 1JEW (EM 22.00A ) 1KAC (X-ray 2.60A ) 1P69 (X-ray 3.10A ) 1P6A (X-ray 2.90A ) 1RSF (NMR - ) 2J12 (X-ray 1.50A ) 2J1K (X-ray 2.30A ) 2NPL (NMR - ) 2W9L (X-ray 2.91A ) 2WBW (X-ray 1.55A ) 3J6L (EM 9.00A ) 3J6M (EM 9.00A ) 3J6N (EM 9.00A ) 3J6O (EM 9.00A ) 7DPZ (EM 3.80A ) 7DQ1 (EM 3.60A ) 7VXZ (EM 3.19A ) 7VYK (EM 2.79A ) 7VYL (EM 2.79A ) 7VYM (EM 3.68A ) 7W14 (EM 2.20A ) |
| DBSNP | rs34727960 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12021372, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15364909}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051}. Cell junction, adherens junction {ECO:0000269|PubMed:12297051}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). {ECO:0000269|PubMed:11316797, ECO:0000269|PubMed:12297051}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:14978041}.; [Isoform 4]: Secreted {ECO:0000269|PubMed:14978041}.; [Isoform 5]: Secreted {ECO:0000269|PubMed:14978041}. |
| Mouse PG classification | NA |
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