Gene Information
Gene NameSTK18
OrganismHomo sapiens (Human)
Gene Length970
Protein NamesSerine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBO00444
Gene CardPLK4
Uniprot IDO00444
PfamPF00069; PF18190; PF18409
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001466(Rat);0.042105(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2N19  (NMR  -  )  3COK  (X-ray  2.25A  )  4JXF  (X-ray  2.40A  )  4N7V  (X-ray  2.76A  )  4N7Z  (X-ray  2.85A  )  4N9J  (X-ray  2.60A  )  4YUR  (X-ray  2.65A  )  4YYP  (X-ray  2.60A  )  5LHY  (X-ray  3.31A  )  5LHZ  (X-ray  2.51A  )  6N45  (X-ray  2.64A  )  6N46  (X-ray  3.71A  )  6W38  (X-ray  4.48A  )  6W3I  (X-ray  3.80A  )  6W3J  (X-ray  4.38A  ) 
DBSNP rs34156294  rs35232579  rs35448573  rs3811740  rs35049837  rs34906574  rs56043017  rs17012739 
Subcellular location [CC]Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27796307}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q64702}. Cleavage furrow {ECO:0000250|UniProtKB:Q64702}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30804208, ECO:0000269|PubMed:32433990}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
Mouse PG classificationNA
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