| Gene Information | |
|---|---|
| Gene Name | CAPS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1296 |
| Protein Names | Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000180881 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86UW7 |
| Gene Card | CADPS2 |
| Uniprot ID | Q86UW7 |
| Pfam | PF06292; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-1.595380412) |
| Ortholog in Animals | Alpaca_ CAPS2 ( ortholog_one2one ) Dog_ CAPS2 ( ortholog_one2one ) GuineaPig_ CAPS2 ( ortholog_one2one ) Macaque_ CAPS2 ( ortholog_one2one ) Mouse_ Caps2 ( ortholog_one2one ) Pig_ CAPS2 ( ortholog_one2one ) Rat_ Caps2 ( ortholog_one2one ) Rabbit_ CAPS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CAPS, PHF24, SPATA21, CAPSL, EFCAB6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen. {ECO:0000269|PubMed:12659812}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17144625 |
| Subcellular location [CC] | Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles. |
| Mouse PG classification | NA |
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