| Gene Information | |
|---|---|
| Gene Name | CAPS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1353 |
| Protein Names | Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) |
| Target Name | calcyphosin |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000105519 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9ULU8 |
| Gene Card | CADPS |
| Uniprot ID | Q9ULU8 |
| Pfam | PF06292; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-1.056994127) |
| Ortholog in Animals | Alpaca_ CAPS ( ortholog_one2one ) Dog_ CAPS ( ortholog_one2one ) GuineaPig_ CAPS ( ortholog_one2one ) Macaque_ CAPS ( ortholog_one2one ) Pig_ CAPS ( ortholog_one2one ) Rat_ Caps ( ortholog_one2one ) |
| Ohnologs | CAPSL |
| Paralogs | PHF24, SPATA21, CAPS2, CAPSL, EFCAB6 |
| Tissue | NA |
| Tissue Specificity | Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. {ECO:0000269|PubMed:12659812}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WI1 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Synapse {ECO:0000250|UniProtKB:Q62717}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:Q62717}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62717}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. {ECO:0000250|UniProtKB:Q62717}. |
| Mouse PG classification | NA |
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