Gene Information
Gene NameKLHL2
OrganismHomo sapiens (Human)
Gene Length593
Protein NamesKelch-like protein 2 (Actin-binding protein Mayven)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000109466 )
Evolutionary StageEumetazoa
AlphaFoldDBO95198
Gene CardKLHL2
Uniprot IDO95198
PfamPF07707; PF00651; PF01344
In ASDno
Allosteric Predictionno (-0.473643432)
Ortholog in AnimalsAlpaca_ KLHL2 ( ortholog_one2one )
Dog_ KLHL2 ( ortholog_one2one )
GuineaPig_ KLHL2 ( ortholog_one2one )
Macaque_ KLHL2 ( ortholog_one2one )
Mouse_ Klhl2 ( ortholog_one2one )
Pig_ KLHL2 ( ortholog_one2one )
Rat_ Klhl2 ( ortholog_one2one )
Rabbit_ KLHL2 ( ortholog_one2one )
OhnologsKLHL3
ParalogsKLHL40, KLHDC7B, GAN, BACH1, KLHL20, KLHL10, KLHL42, KLHL21, KLHL32, KBTBD7, KBTBD6, BACH2, KLHL30, KLHL15, KLHL38, KLHL41, KLHL26, KLHL17, KBTBD3, KLHL13, KLHL9, KLHL18, KLHL23, KLHDC7A, KLHL31, IVNS1ABP, KLHL1, KEAP1, KLHL8, KLHL29, KBTBD12, KLHL34, KLHL7, KLHL33, KLHL36, KLHL28, KBTBD11, KLHL14, CCIN, BTBD18, IPP, KLHDC8B, KLHL6, KLHL24, KLHL5, KBTBD13, KBTBD8, KLHL3, KLHL35, KLHL22, KBTBD2, KLHL12, KLHL4, KLHDC8A
TissueNA
Tissue SpecificityUbiquitous. Detected throughout the brain. {ECO:0000269|PubMed:10397770}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.011111(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2XN4  (X-ray  1.99A  4CHB  (X-ray  1.56A 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250}.
Mouse PG classificationNA
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