Gene Information
Gene NameCAPN3
OrganismHomo sapiens (Human)
Gene Length821
Protein NamesCalpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)
Target Namecalpain-3
Target TypeNA
Gene Age886 ( ENSG00000092529 )
Evolutionary StageEukaryota
AlphaFoldDBP20807
Gene CardCAPN3
Uniprot IDP20807
PfamPF01067; PF13833; PF00648
In ASDno
Allosteric Predictionyes (0.27315928)
Ortholog in AnimalsAlpaca_ CAPN3 ( ortholog_one2one )
Dog_ CAPN3 ( ortholog_one2one )
GuineaPig_ CAPN3 ( ortholog_one2one )
Macaque_ CAPN3 ( ortholog_one2one )
Mouse_ Capn3 ( ortholog_one2one )
Pig_ CAPN3 ( ortholog_one2one )
Rat_ Capn3 ( ortholog_one2one )
Rabbit_ CAPN3 ( ortholog_one2one )
OhnologsCAPN1, CAPN9, CAPN11, CAPN2
ParalogsCAPN1, PEF1, GCA, SRI, CAPN9, PDCD6, CAPN2, CAPN5, CAPN14, CAPN15, CAPN7, ADGB, CAPN6, CAPN8, CAPN12, CAPNS2, CAPN11, CAPN13, CAPNS1, CAPN10
Tissueskeletal.muscle
Tissue SpecificityIsoform I is skeletal muscle specific.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4OKH  (X-ray  2.45A  )  6BDT  (X-ray  2.30A  )  6BGP  (X-ray  2.75A  )  6BJD  (X-ray  2.80A  )  6BKJ  (X-ray  3.20A  ) 
DBSNP rs140660066  rs28364364  rs762020512  rs121434546  rs1801505  rs1566973583  rs17592  rs35889956  rs758795961  rs369784333  rs773001194  rs1345121557  rs1555420634  rs1801449  rs121434547  rs1555421271  rs267606703  rs777483913  rs777323132  rs773827877  rs776043976  rs776043976  rs863224956  rs201736037  rs147764579  rs863224957  rs121434548  rs141656719  rs557164942  rs761637940  rs148044781  rs398123143  rs727503839  rs121434544  rs863224959  rs199806879  rs11557723  rs886042557  rs750083132  rs587780290  rs80338802  rs149095128 
Subcellular location [CC]Cytoplasm. Nucleus, nucleolus {ECO:0000269|PubMed:23357851, ECO:0000269|PubMed:27657329}.
Mouse PG classificationNA
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