| Gene Information | |
|---|---|
| Gene Name | CAPG |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Macrophage-capping protein (Actin regulatory protein CAP-G) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000042493 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P40121 |
| Gene Card | CAPG |
| Uniprot ID | P40121 |
| Pfam | PF00626 |
| In ASD | no |
| Allosteric Prediction | no (-0.220737441) |
| Ortholog in Animals | Alpaca_ CAPG ( ortholog_one2one ) Dog_ CAPG ( ortholog_one2one ) GuineaPig_ CAPG ( ortholog_one2one ) Macaque_ CAPG ( ortholog_one2one ) Mouse_ Capg ( ortholog_one2one ) Pig_ CAPG ( ortholog_one2one ) Rat_ Capg ( ortholog_one2one ) Rabbit_ CAPG ( ortholog_one2one ) |
| Ohnologs | SCIN, VILL |
| Paralogs | VIL1, VILL, SCIN, SVIL, AVIL, FLII, GSN |
| Tissue | NA |
| Tissue Specificity | Macrophages and macrophage-like cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J72 (X-ray 2.50A ) 1JHW (X-ray 2.80A ) |
| DBSNP | rs2229668 rs11539103 rs6886 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18266911}. Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P24452}. Cell projection, ruffle {ECO:0000250|UniProtKB:P24452}. Note=In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia. {ECO:0000250|UniProtKB:P24452}. |
| Mouse PG classification | NA |
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