| Gene Information | |
|---|---|
| Gene Name | GFRA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000151892 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P56159 |
| Gene Card | GFRA1 |
| Uniprot ID | P56159 |
| Pfam | PF02351 |
| In ASD | no |
| Allosteric Prediction | yes (0.038836385) |
| Ortholog in Animals | Alpaca_ GFRA1 ( ortholog_one2one ) Dog_ GFRA1 ( ortholog_one2one ) GuineaPig_ GFRA1 ( ortholog_one2one ) Macaque_ GFRA1 ( ortholog_one2one ) Mouse_ Gfra1 ( ortholog_one2one ) Pig_ GFRA1 ( ortholog_one2one ) Rat_ AABR07007068.1 ( ortholog_one2one ) Rabbit_ GFRA1 ( ortholog_one2one ) |
| Ohnologs | GFRA2 |
| Paralogs | GFRA4, GFRA2, GFRA3, GFRAL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6Q2N (EM 4.40A ) |
| DBSNP | rs8192662 rs2072276 rs924541616 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. {ECO:0000250|UniProtKB:Q62997}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |