| Gene Information | |
|---|---|
| Gene Name | CAMSAP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1249 |
| Protein Names | Calmodulin-regulated spectrin-associated protein 3 (Protein Nezha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000076826 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9P1Y5 |
| Gene Card | CAMSAP3 |
| Uniprot ID | Q9P1Y5 |
| Pfam | PF17095; PF11971; PF08683 |
| In ASD | no |
| Allosteric Prediction | no (-0.748557805) |
| Ortholog in Animals | Alpaca_ CAMSAP3 ( ortholog_one2one ) Dog_ CAMSAP3 ( ortholog_one2one ) GuineaPig_ CAMSAP3 ( ortholog_one2one ) Macaque_ CAMSAP3 ( ortholog_one2one ) Mouse_ Camsap3 ( ortholog_one2one ) Pig_ CAMSAP3 ( ortholog_one2one ) Rat_ Camsap3 ( ortholog_one2one ) Rabbit_ CAMSAP3 ( ortholog_one2one ) |
| Ohnologs | CAMSAP2 |
| Paralogs | CAMSAP2, CAMSAP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3745358 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:28386021}. Cell junction, adherens junction {ECO:0000269|PubMed:19041755}. Cytoplasm {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q80VC9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80VC9}. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:19041755, PubMed:24486153, PubMed:27693509). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). Localizes along zonula adherens only at mature cell-cell contacts (PubMed:19041755). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (By similarity). This cytokinetic bridge does not undergo stereotypical abscission after cell division (By similarity). Accumulates to the pericentrosomal region following interaction with KATNA1 (PubMed:28386021). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:28386021}. |
| Mouse PG classification | NA |
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