| Gene Information | |
|---|---|
| Gene Name | NOS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1203 |
| Protein Names | Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII) |
| Target Name | nitric oxide synthase, endothelial |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000164867 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P29474 |
| Gene Card | NOS3 |
| Uniprot ID | P29474 |
| Pfam | PF00667; PF00258; PF00175; PF02898 |
| In ASD | yes |
| Allosteric Prediction | yes (1.39222894) |
| Ortholog in Animals | Alpaca_ NOS3 ( ortholog_one2one ) GuineaPig_ NOS3 ( ortholog_one2one ) Macaque_ NOS3 ( ortholog_one2one ) Mouse_ Nos3 ( ortholog_one2one ) Pig_ NOS3 ( ortholog_one2one ) Rat_ Nos3 ( ortholog_one2one ) Rabbit_ NOS3 ( ortholog_one2one ) |
| Ohnologs | NOS1 |
| Paralogs | POR, MTRR, NOS1, NDOR1, NOS2 |
| Tissue | spleen |
| Tissue Specificity | Platelets, placenta, liver and kidney. {ECO:0000269|PubMed:7515611}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1M9J (X-ray 2.43A ) 1M9K (X-ray 2.01A ) 1M9M (X-ray 1.96A ) 1M9Q (X-ray 2.01A ) 1M9R (X-ray 2.56A ) 1NIW (X-ray 2.05A ) 2LL7 (NMR - ) 2MG5 (NMR - ) 2N8J (NMR - ) 3EAH (X-ray 2.44A ) 3NOS (X-ray 2.40A ) 4D1O (X-ray 1.82A ) 4D1P (X-ray 1.73A ) 5UO8 (X-ray 2.18A ) 5UO9 (X-ray 2.19A ) 5UOA (X-ray 2.20A ) 5UOB (X-ray 2.29A ) 5UOC (X-ray 2.20A ) 5VVB (X-ray 2.15A ) 5VVC (X-ray 2.40A ) 5VVD (X-ray 2.25A ) 5XOF (X-ray 1.96A ) 6AV6 (X-ray 2.08A ) 6AV7 (X-ray 1.92A ) 6CIE (X-ray 1.95A ) 6CIF (X-ray 2.20A ) 6NH1 (X-ray 2.22A ) 6NH2 (X-ray 2.29A ) 6NH3 (X-ray 2.01A ) 6NH4 (X-ray 2.27A ) 6NH5 (X-ray 1.96A ) 6NH6 (X-ray 2.19A ) 6NH7 (X-ray 1.90A ) 6NH8 (X-ray 1.80A ) 6NHF (X-ray 1.83A ) 6POU (X-ray 2.19A ) 6POV (X-ray 2.05A ) 6POW (X-ray 2.15A ) 6POX (X-ray 2.20A ) 6POY (X-ray 2.30A ) 6POZ (X-ray 2.20A ) 6PP0 (X-ray 1.97A ) 6PP1 (X-ray 1.76A ) 6PP2 (X-ray 2.02A ) 6PP3 (X-ray 1.95A ) 6PP4 (X-ray 2.20A ) 7M56 (X-ray 1.96A ) 7TSG (X-ray 1.85A ) 7TSH (X-ray 2.15A ) 7TSI (X-ray 2.10A ) 7TSK (X-ray 2.05A ) 7TSL (X-ray 1.90A ) 7TSM (X-ray 1.85A ) 7TSN (X-ray 2.08A ) 7TSO (X-ray 2.00A ) 7TSP (X-ray 2.00A ) 7UAO (X-ray 1.90A ) |
| DBSNP | rs3918166 rs1799983 rs145805216 rs145168353 rs7792133 rs3918232 rs3918201 rs3918234 |
| Subcellular location [CC] | Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. |
| Mouse PG classification | HPG |
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