| Gene Information | |
|---|---|
| Gene Name | S1PR5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8) |
| Target Name | sphingosine-1-phosphate receptor 5 |
| Target Type | Clinical trial target |
| Gene Age | 25 ( ENSG00000180739 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H228 |
| Gene Card | S1PR5 |
| Uniprot ID | Q9H228 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.996175842) |
| Ortholog in Animals | Dog_ S1PR5 ( ortholog_one2one ) Macaque_ S1PR5 ( ortholog_one2one ) Mouse_ S1pr5 ( ortholog_one2one ) Pig_ S1PR5 ( ortholog_one2one ) Rat_ S1pr5 ( ortholog_one2one ) Rabbit_ S1PR5 ( ortholog_one2one ) |
| Ohnologs | LPAR2, S1PR4, S1PR1, LPAR3, LPAR1, S1PR3 |
| Paralogs | GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, LPAR1, LPAR2, LPAR3, S1PR2, S1PR1, S1PR3, S1PR4 |
| Tissue | bone.marrow, brain, skin, spleen |
| Tissue Specificity | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:11705398, ECO:0000269|PubMed:12234605, ECO:0000269|PubMed:12427546}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7EW1 (EM 3.40A ) 7YXA (X-ray 2.20A ) |
| DBSNP | rs35483143 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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