| Gene Information | |
|---|---|
| Gene Name | CALD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 793 |
| Protein Names | Caldesmon (CDM) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000122786 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q05682 |
| Gene Card | CALD1 |
| Uniprot ID | Q05682 |
| Pfam | PF02029 |
| In ASD | no |
| Allosteric Prediction | no (-0.039954576) |
| Ortholog in Animals | Alpaca_ CALD1 ( ortholog_one2one ) Dog_ CALD1 ( ortholog_one2one ) GuineaPig_ CALD1 ( ortholog_one2one ) Macaque_ CALD1 ( ortholog_one2one ) Mouse_ Cald1 ( ortholog_one2one ) Pig_ CALD1 ( ortholog_one2one ) Rat_ Cald1 ( ortholog_one2one ) Rabbit_ CALD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LSP1 |
| Tissue | NA |
| Tissue Specificity | High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6973420 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P13505}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:P13505}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P13505}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250|UniProtKB:P13505}. |
| Mouse PG classification | NA |
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