| Gene Information | |
|---|---|
| Gene Name | SIDT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 832 |
| Protein Names | SID1 transmembrane family member 2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000149577 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NBJ9 |
| Gene Card | SIDT2 |
| Uniprot ID | Q8NBJ9 |
| Pfam | PF13965 |
| In ASD | no |
| Allosteric Prediction | no (-0.707323422) |
| Ortholog in Animals | Alpaca_ SIDT2 ( ortholog_one2one ) Dog_ SIDT2 ( ortholog_one2one ) GuineaPig_ SIDT2 ( ortholog_one2one ) Macaque_ SIDT2 ( ortholog_one2one ) Mouse_ Sidt2 ( ortholog_one2one ) Pig_ SIDT2 ( ortholog_one2one ) Rat_ Sidt2 ( ortholog_one2one ) Rabbit_ SIDT2 ( ortholog_one2one ) |
| Ohnologs | SIDT1 |
| Paralogs | SIDT1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12285035 rs17120425 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:28277980}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Cell membrane {ECO:0000269|PubMed:28277980}. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:28277980}. |
| Mouse PG classification | NA |
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