| Gene Information | |
|---|---|
| Gene Name | CAK |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P50613 |
| Gene Card | CDK7 |
| Uniprot ID | P50613 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.251518(Rat);0.096116(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UA2 (X-ray 3.02A ) 6O9L (EM 7.20A ) 6XBZ (EM 2.80A ) 6XD3 (EM 3.30A ) 7B5O (EM 2.50A ) 7B5Q (EM 2.50A ) 7EGB (EM 3.30A ) 7EGC (EM 3.90A ) 7ENA (EM 4.07A ) 7ENC (EM 4.13A ) 7LBM (EM 4.80A ) 7NVR (EM 4.50A ) |
| DBSNP | rs34584424 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (PubMed:19071173). {ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. |
| Mouse PG classification | NA |
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