| Gene Information | |
|---|---|
| Gene Name | CAK |
| Organism | Homo sapiens (Human) |
| Gene Length | 913 |
| Protein Names | Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q08345 |
| Gene Card | DDR1 |
| Uniprot ID | Q08345 |
| Pfam | PF00754; PF07714 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. {ECO:0000269|PubMed:7845687, ECO:0000269|PubMed:7848919, ECO:0000269|PubMed:8247543}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3ZOS (X-ray 1.92A ) 4AG4 (X-ray 2.80A ) 4BKJ (X-ray 1.70A ) 4CKR (X-ray 2.20A ) 5BVK (X-ray 2.29A ) 5BVN (X-ray 2.21A ) 5BVO (X-ray 1.98A ) 5BVW (X-ray 1.94A ) 5FDP (X-ray 2.25A ) 5FDX (X-ray 2.65A ) 5SAU (X-ray 1.80A ) 5SAV (X-ray 1.76A ) 5SAW (X-ray 1.60A ) 5SAX (X-ray 1.90A ) 5SAY (X-ray 2.19A ) 5SAZ (X-ray 1.80A ) 5SB0 (X-ray 1.97A ) 5SB1 (X-ray 1.53A ) 5SB2 (X-ray 1.60A ) 6BRJ (X-ray 2.23A ) 6BSD (X-ray 2.61A ) 6FEW (X-ray 1.44A ) 6FEX (X-ray 1.29A ) 6FIL (X-ray 1.73A ) 6FIN (X-ray 1.67A ) 6FIO (X-ray 1.99A ) 6FIQ (X-ray 1.79A ) 6GWR (X-ray 2.07A ) 6HP9 (X-ray 1.96A ) 6Y23 (X-ray 2.58A ) 7BCM (X-ray 2.30A ) 7BE6 (X-ray 1.87A ) 7FEH (X-ray 1.61A ) |
| DBSNP | rs55901302 rs34544756 rs55980643 rs56231803 rs56024191 rs2524235 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted {ECO:0000305}.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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