| Gene Information | |
|---|---|
| Gene Name | FKBP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 412 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000105701 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q14318 |
| Gene Card | FKBP8 |
| Uniprot ID | Q14318 |
| Pfam | PF00254; PF07719 |
| In ASD | no |
| Allosteric Prediction | no (-0.151165357) |
| Ortholog in Animals | Alpaca_ FKBP8 ( ortholog_one2one ) Dog_ FKBP8 ( ortholog_one2one ) GuineaPig_ FKBP8 ( ortholog_one2one ) Macaque_ FKBP8 ( ortholog_one2one ) Mouse_ Fkbp8 ( ortholog_one2one ) Pig_ FKBP8 ( ortholog_one2one ) Rat_ Fkbp8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FKBP11, FKBP14, FKBP3, TTC9, FKBP10, FKBP1A, FKBP1C, FKBP1B, FKBP7, FKBP2, TTC9B, TTC9C, FKBPL, FKBP5, FKBP4, FKBP15, FKBP9, FKBP6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. {ECO:0000269|PubMed:18385096}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2AWG (X-ray 1.60A ) 2D9F (NMR - ) 2F2D (NMR - ) 2MF9 (NMR - ) 3EY6 (X-ray 1.05A ) 5MGX (X-ray 2.18A ) |
| DBSNP | rs11574806 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:16176796}. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; [Isoform 1]: Mitochondrion membrane {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; [Isoform 3]: Mitochondrion membrane {ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}. |
| Mouse PG classification | NA |
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