| Gene Information | |
|---|---|
| Gene Name | POLR1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1135 |
| Protein Names | DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000125630 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H9Y6 |
| Gene Card | POLR1B |
| Uniprot ID | Q9H9Y6 |
| Pfam | PF06883; PF04563; PF04561; PF04565; PF00562; PF04560 |
| In ASD | no |
| Allosteric Prediction | yes (0.132091611) |
| Ortholog in Animals | Alpaca_ POLR1B ( ortholog_one2one ) Dog_ POLR1B ( ortholog_one2one ) GuineaPig_ POLR1B ( ortholog_one2one ) Macaque_ POLR1B ( ortholog_one2one ) Mouse_ Polr1b ( ortholog_one2one ) Pig_ POLR1B ( ortholog_one2one ) Rat_ Polr1b ( ortholog_one2one ) Rabbit_ POLR1B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POLR3B, POLR2B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.017111(Rat);0.031906(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7OB9 (EM 2.70A ) 7OBA (EM 3.10A ) 7OBB (EM 3.30A ) 7VBA (EM 2.89A ) 7VBB (EM 2.81A ) 7VBC (EM 3.01A ) 8A43 (EM 4.09A ) |
| DBSNP | rs1545133 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:11250903}. Chromosome {ECO:0000250|UniProtKB:P70700}. |
| Mouse PG classification | NA |
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