| Gene Information | |
|---|---|
| Gene Name | PEPE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1247 |
| Protein Names | SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O94885 |
| Gene Card | SASH1 |
| Uniprot ID | O94885 |
| Pfam | PF00536; PF07647; PF07653; PF12485 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes (PubMed:23333244, PubMed:26203640). {ECO:0000269|PubMed:12771949, ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:26203640}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DL0 (NMR - ) 2EBP (NMR - ) |
| DBSNP | rs35078400 rs1562489143 rs1562489156 rs1237876014 rs1562489224 rs1562489240 rs1562490566 rs1562490566 rs1562491501 rs587781245 rs208696 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23333244}. |
| Mouse PG classification | NA |
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