| Gene Information | |
|---|---|
| Gene Name | MCM3AP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1980 |
| Protein Names | Germinal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000160294 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60318 |
| Gene Card | MCM3AP |
| Uniprot ID | O60318 |
| Pfam | PF16766; PF16769; PF16768; PF03399 |
| In ASD | no |
| Allosteric Prediction | no (-1.025570297) |
| Ortholog in Animals | Alpaca_ MCM3AP ( ortholog_one2one ) Dog_ MCM3AP ( ortholog_one2one ) GuineaPig_ MCM3AP ( ortholog_one2one ) Macaque_ MCM3AP ( ortholog_one2one ) Mouse_ Mcm3ap ( ortholog_one2one ) Pig_ MCM3AP ( ortholog_one2one ) Rat_ Mcm3ap ( ortholog_one2one ) Rabbit_ MCM3AP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LENG8, SAC3D1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:11024281). Up-regulated in germinal center B-cells in tonsils (at protein level) (PubMed:11024281). {ECO:0000269|PubMed:11024281}. |
| Pharmacological Animal Models | 0.034251(Chimpanzee);0.065465(Mouse);NULL(Rat);0.045455(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4DHX (X-ray 2.10A ) |
| DBSNP | rs9975588 rs17182545 rs17182552 rs773228537 rs17182566 rs373674344 rs483352869 rs17182850 rs17182857 rs779248881 rs17176709 rs17183220 rs17183248 rs779630101 rs17183290 rs2298697 rs17176933 rs17183403 |
| Subcellular location [CC] | [Isoform GANP]: Nucleus envelope {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:21195085, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:28633435}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20005110}. Chromosome {ECO:0000269|PubMed:23652018}. Note=Predominantly located at the nuclear envelope, facing the nucleus interior (PubMed:20005110, PubMed:21195085, PubMed:23591820). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (PubMed:23591820, PubMed:22307388). Also found associated with chromatin (PubMed:23652018). In B-cells, targeted to the immunoglobulin variable region genes (PubMed:23652018). {ECO:0000269|PubMed:20005110, ECO:0000269|PubMed:21195085, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:23652018}.; [Isoform MCM3AP]: Cytoplasm {ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:21195085}. Nucleus {ECO:0000269|PubMed:12226073, ECO:0000269|PubMed:21195085}. Note=Translocates into the nucleus in the presence of MCM3 (PubMed:12226073). Associates with chromatin possibly through interaction with MCM3 (PubMed:12226073). {ECO:0000269|PubMed:12226073}. |
| Mouse PG classification | NA |
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