| Gene Information | |
|---|---|
| Gene Name | CACNA2D4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1137 |
| Protein Names | Voltage-dependent calcium channel subunit alpha-2/delta-4 (Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4] |
| Target Name | voltage-dependent calcium channel |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000151062 ) 3 ( ENSG00000284953 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z3S7 |
| Gene Card | CACNA2D4 |
| Uniprot ID | Q7Z3S7 |
| Pfam | PF08473; PF13768; PF08399 |
| In ASD | no |
| Allosteric Prediction | yes (0.258440723) |
| Ortholog in Animals | Alpaca_ CACNA2D4 ( ortholog_one2one ) Dog_ DCP1B ( ortholog_one2one ) GuineaPig_ CACNA2D4 ( ortholog_one2one ) Macaque_ CACNA2D4 ( ortholog_one2one ) Mouse_ Cacna2d4 ( ortholog_one2one ) Pig_ CACNA2D4 ( ortholog_one2one ) Rat_ Cacna2d4 ( ortholog_one2one ) |
| Ohnologs | CACNA2D2, CACNA2D3 |
| Paralogs | CACHD1, CACNA2D2, CACNA2D3, CACNA2D1 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). {ECO:0000269|PubMed:12181424}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10735005 rs36077411 rs35331095 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | HPG |
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