| Gene Information | |
|---|---|
| Gene Name | CACNA2D3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1091 |
| Protein Names | Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3] |
| Target Name | voltage-dependent calcium channel |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000157445 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IZS8 |
| Gene Card | CACNA2D3 |
| Uniprot ID | Q8IZS8 |
| Pfam | PF08473; PF13768; PF08399 |
| In ASD | no |
| Allosteric Prediction | yes (0.57733827) |
| Ortholog in Animals | Alpaca_ CACNA2D3 ( ortholog_one2one ) Dog_ CACNA2D3 ( ortholog_one2one ) GuineaPig_ CACNA2D3 ( ortholog_one2one ) Macaque_ CACNA2D3 ( ortholog_one2one ) Mouse_ Cacna2d3 ( ortholog_one2one ) Pig_ CACNA2D3 ( ortholog_one2one ) Rat_ Cacna2d3 ( ortholog_one2one ) Rabbit_ CACNA2D3 ( ortholog_one2one ) |
| Ohnologs | CACNA2D4, CACNA2D1 |
| Paralogs | CACHD1, CACNA2D2, CACNA2D4, CACNA2D1 |
| Tissue | NA |
| Tissue Specificity | Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed. {ECO:0000269|PubMed:11687876}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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