| Gene Information | |
|---|---|
| Gene Name | CD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 668 |
| Protein Names | T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6] |
| Target Name | t-cell differentiation antigen cd6 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000013725 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P30203 |
| Gene Card | CD6 |
| Uniprot ID | P30203 |
| Pfam | PF00530 |
| In ASD | no |
| Allosteric Prediction | yes (0.050320666) |
| Ortholog in Animals | Alpaca_ CD6 ( ortholog_one2one ) Dog_ CD6 ( ortholog_one2one ) GuineaPig_ CD6 ( ortholog_one2one ) Macaque_ CD6 ( ortholog_one2one ) Mouse_ Cd6 ( ortholog_one2one ) Pig_ CD6 ( ortholog_one2one ) Rat_ Cd6 ( ortholog_one2one ) Rabbit_ CD6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LOX, SSC4D, SSC5D, LGALS3BP, LOXL4, SCART1, CD163, PRSS12, DMBT1, LOXL3, CD5, LOXL1, CD5L, LOXL2, CD163L1 |
| Tissue | appendix, lymph.node, spleen |
| Tissue Specificity | Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:9013954}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5A2E (X-ray 3.15A ) |
| DBSNP | rs11230562 rs11230563 rs2074225 rs12360861 rs34974368 rs2074233 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17371992, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:9013954}; Single-pass type I membrane protein {ECO:0000269|PubMed:17371992}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269|PubMed:15294938}.; [Soluble CD6]: Secreted {ECO:0000269|PubMed:17601777}. Note=The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. {ECO:0000305}. |
| Mouse PG classification | NA |
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