| Gene Information | |
|---|---|
| Gene Name | SGPP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 399 |
| Protein Names | Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000163082 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IWX5 |
| Gene Card | SGPP2 |
| Uniprot ID | Q8IWX5 |
| Pfam | PF01569 |
| In ASD | no |
| Allosteric Prediction | no (-0.76233217) |
| Ortholog in Animals | Alpaca_ SGPP2 ( ortholog_one2one ) Dog_ SGPP2 ( ortholog_one2one ) GuineaPig_ SGPP2 ( ortholog_one2one ) Macaque_ SGPP2 ( ortholog_one2one ) Mouse_ Sgpp2 ( ortholog_one2one ) Pig_ SGPP2 ( ortholog_one2one ) Rat_ Sgpp2 ( ortholog_one2one ) Rabbit_ SGPP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SGPP1, PLPP7, PLPP6 |
| Tissue | NA |
| Tissue Specificity | Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO:0000269|PubMed:12411432}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12411432}; Multi-pass membrane protein {ECO:0000269|PubMed:12411432}. |
| Mouse PG classification | NA |
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