Gene Information
Gene NameCACNA1B
OrganismHomo sapiens (Human)
Gene Length2339
Protein NamesVoltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2)
Target Namevoltage-dependent n-type calcium channel
Target TypeNA
Gene Age810 ( ENSG00000148408 )
Evolutionary StageEumetazoa
AlphaFoldDBQ00975
Gene CardCACNA1B
Uniprot IDQ00975
PfamPF08763; PF16905; PF00520
In ASDyes
Allosteric Predictionyes (1.711344463)
Ortholog in AnimalsAlpaca_ CACNA1B ( ortholog_one2one )
GuineaPig_ CACNA1B ( ortholog_one2one )
Macaque_ CACNA1B ( ortholog_one2one )
Mouse_ Cacna1b ( ortholog_one2one )
Pig_ CACNA1B ( ortholog_one2one )
Rat_ Cacna1b ( ortholog_one2one )
Rabbit_ CACNA1B ( ortholog_one2one )
OhnologsCACNA1A, CACNA1E
ParalogsSCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
Tissuecerebellar.hemisphere, cerebellum, cerebral.cortex
Tissue SpecificityIsoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum (PubMed:30982612). {ECO:0000269|PubMed:30982612}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2LCM  (NMR  -  )  7MIX  (EM  3.00A  )  7MIY  (EM  3.10A  )  7VFS  (EM  2.80A  )  7VFU  (EM  3.00A  )  7VFV  (EM  3.00A  )  7VFW  (EM  3.30A  ) 
DBSNP rs4422842  rs7873074  rs11137342  rs184841813  rs1322525317  rs12377346 
Subcellular location [CC]Membrane {ECO:0000269|PubMed:34234349};
Multi-pass membrane protein {ECO:0000269|PubMed:34234349}.
Mouse PG classificationNA
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