| Gene Information | |
|---|---|
| Gene Name | KIF1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1816 |
| Protein Names | Kinesin-like protein KIF1B (Klp) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000054523 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60333 |
| Gene Card | KIF1B |
| Uniprot ID | O60333 |
| Pfam | PF12473; PF00498; PF12423; PF00225; PF16183; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.345735729) |
| Ortholog in Animals | Alpaca_ KIF1B ( ortholog_one2one ) GuineaPig_ KIF1B ( ortholog_one2one ) Macaque_ KIF1B ( ortholog_one2one ) Mouse_ Kif1b ( ortholog_one2one ) Pig_ KIF1B ( ortholog_one2one ) Rat_ Pgd ( ortholog_one2one ) Rabbit_ KIF1B ( ortholog_one2one ) |
| Ohnologs | KIF1C, KIF1A |
| Paralogs | KIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF4A, KIF2A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF1A, KIF3B, KIF3C, CENPE, KIF26A, KIF23, KIF7, KIF5A, KIF18B, KIF25, KIF9, KIF6, KIF14, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF24, KIF2C, KIF21A, KIF19, KIF17, KIF5C, KIF18A |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas. {ECO:0000269|PubMed:10762626, ECO:0000269|PubMed:11526494, ECO:0000269|PubMed:12888911}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EH0 (NMR - ) |
| DBSNP | rs1269940164 rs121908160 rs121908161 rs121908162 rs2297881 rs121908163 rs121908164 rs77172218 rs143669846 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Mitochondrion {ECO:0000269|PubMed:16225668}. Cell projection, axon {ECO:0000250|UniProtKB:Q60575}.; [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O88658}. |
| Mouse PG classification | LPG |
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