| Gene Information | |
|---|---|
| Gene Name | CACH5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2339 |
| Protein Names | Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q00975 |
| Gene Card | CACNA1B |
| Uniprot ID | Q00975 |
| Pfam | PF08763; PF16905; PF00520 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum (PubMed:30982612). {ECO:0000269|PubMed:30982612}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LCM (NMR - ) 7MIX (EM 3.00A ) 7MIY (EM 3.10A ) 7VFS (EM 2.80A ) 7VFU (EM 3.00A ) 7VFV (EM 3.00A ) 7VFW (EM 3.30A ) |
| DBSNP | rs4422842 rs7873074 rs11137342 rs184841813 rs1322525317 rs12377346 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:34234349}; Multi-pass membrane protein {ECO:0000269|PubMed:34234349}. |
| Mouse PG classification | NA |
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