Gene Information
Gene NameADAM10
OrganismHomo sapiens (Human)
Gene Length748
Protein NamesDisintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Target Namedisintegrin and metalloproteinase domain-containing protein 10
Target TypeNA
Gene Age1292 ( ENSG00000137845 )
Evolutionary StageOpisthokonta
AlphaFoldDBO14672
Gene CardADAM10
Uniprot IDO14672
PfamPF00200; PF01562
In ASDno
Allosteric Predictionyes (0.443897968)
Ortholog in AnimalsAlpaca_ ADAM10 ( ortholog_one2one )
Dog_ ADAM10 ( ortholog_one2one )
GuineaPig_ ADAM10 ( ortholog_one2one )
Macaque_ ADAM10 ( ortholog_one2one )
Mouse_ Adam10 ( ortholog_one2one )
Pig_ ADAM10 ( ortholog_one2one )
Rat_ Adam10 ( ortholog_one2one )
Rabbit_ ADAM10 ( ortholog_one2one )
OhnologsNA
ParalogsADAM20, ADAM33, ADAM19, ADAM17, ADAM9, ADAM28, ADAM32, ADAM21, ADAM22, ADAM2, ADAM15, ADAM29, ADAM7, ADAM23, ADAM18, ADAMDEC1, ADAM30, ADAM12, ADAM8, ADAM11
TissueNA
Tissue SpecificityExpressed in the brain (at protein level) (PubMed:23676497). Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver (PubMed:11511685, PubMed:9016778). {ECO:0000269|PubMed:11511685, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:9016778}.
Pharmacological Animal Models0.013343(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6BDZ  (X-ray  3.10A  )  6BE6  (X-ray  2.80A  ) 
DBSNP rs483352912  rs61751103  rs267604273  rs145518263  rs483352916 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20624979, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:24990881, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:29430990, ECO:0000269|PubMed:30463011};
Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:12475894};
Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:12475894}. Cell projection, axon {ECO:0000250|UniProtKB:O35598}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35598}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized in the plasma membrane but is also expressed in the Golgi apparatus and in clathrin-coated vesicles derived likely from the Golgi (PubMed:12475894). During long term depression, it is recruited to the cell membrane by DLG1 (PubMed:23676497). The immature form is mainly located near cytoplasmic fibrillar structures, while the mature form is predominantly located at zonula adherens and the cell membrane (PubMed:30463011). The localization and clustering of mature ADAM10 to zonula adherens is regulated by AFDN, TSPAN33, PLEKHA7 and PDZD11 (PubMed:30463011). {ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:30463011}.
Mouse PG classificationNA
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