| Gene Information | |
|---|---|
| Gene Name | UBXDC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 441 |
| Protein Names | UBX domain-containing protein 6 (UBX domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BZV1 |
| Gene Card | UBXN6 |
| Uniprot ID | Q9BZV1 |
| Pfam | PF09409; PF00789 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Enhanced expression in testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6SAP (NMR - ) |
| DBSNP | rs1127888 rs35436704 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18656546}. Cytoplasm, cytosol {ECO:0000269|PubMed:19275885}. Membrane {ECO:0000269|PubMed:19275885}; Peripheral membrane protein {ECO:0000269|PubMed:19275885}. Nucleus {ECO:0000269|PubMed:18656546}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18656546}. Early endosome membrane {ECO:0000269|PubMed:21822278}; Peripheral membrane protein {ECO:0000305|PubMed:19275885}. Late endosome membrane {ECO:0000269|PubMed:21822278}; Peripheral membrane protein {ECO:0000305|PubMed:19275885}. Lysosome membrane {ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:27753622}; Peripheral membrane protein {ECO:0000305|PubMed:19275885}. Note=Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). {ECO:0000269|PubMed:18656546, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:27753622}. |
| Mouse PG classification | NA |
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