| Gene Information | |
|---|---|
| Gene Name | CA9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 459 |
| Protein Names | Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1) |
| Target Name | carbonic anhydrase ix |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000107159 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q16790 |
| Gene Card | CA9 |
| Uniprot ID | Q16790 |
| Pfam | PF00194 |
| In ASD | no |
| Allosteric Prediction | yes (0.859164404) |
| Ortholog in Animals | Alpaca_ CA9 ( ortholog_one2one ) Dog_ CA9 ( ortholog_one2one ) GuineaPig_ CA9 ( ortholog_one2one ) Macaque_ CA9 ( ortholog_one2one ) Mouse_ Car9 ( ortholog_one2one ) Pig_ CA9 ( ortholog_one2one ) Rat_ Ca9 ( ortholog_one2one ) Rabbit_ CA9 ( ortholog_one2one ) |
| Ohnologs | CA12, CA14 |
| Paralogs | CA5B, CA1, CA8, CA2, CA12, CA7, CA14, CA3, CA13, CA4, CA5A, CA6, CA11, CA10 |
| Tissue | stomach |
| Tissue Specificity | Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2HKF (X-ray 2.01A ) 3IAI (X-ray 2.20A ) 5DVX (X-ray 1.60A ) 5FL4 (X-ray 1.82A ) 5FL5 (X-ray 2.05A ) 5FL6 (X-ray 1.95A ) 6FE0 (X-ray 1.91A ) 6FE1 (X-ray 1.95A ) 6FE2 (X-ray 1.87A ) 6G98 (X-ray 2.47A ) 6G9U (X-ray 1.75A ) 6QN2 (X-ray 1.95A ) 6QN5 (X-ray 1.96A ) 6QN6 (X-ray 2.25A ) 6QUT (X-ray 1.96A ) 6RQN (X-ray 1.78A ) 6RQQ (X-ray 1.28A ) 6RQU (X-ray 1.39A ) 6RQW (X-ray 1.49A ) 6TL5 (X-ray 2.21A ) 6TL6 (X-ray 2.15A ) 6Y74 (X-ray 1.53A ) 7POM (X-ray 1.98A ) |
| DBSNP | rs2071676 rs3829078 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. |
| Mouse PG classification | NA |
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