| Gene Information | |
|---|---|
| Gene Name | CA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 312 |
| Protein Names | Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) |
| Target Name | carbonic anhydrase 4 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000167434 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P22748 |
| Gene Card | CA4 |
| Uniprot ID | P22748 |
| Pfam | PF00194 |
| In ASD | no |
| Allosteric Prediction | yes (0.030834253) |
| Ortholog in Animals | Alpaca_ CA4 ( ortholog_one2one ) Dog_ CA4 ( ortholog_one2one ) GuineaPig_ CA4 ( ortholog_one2one ) Macaque_ CA4 ( ortholog_one2one ) Mouse_ Car4 ( ortholog_one2one ) Pig_ CA4 ( ortholog_one2one ) Rat_ Ca4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CA9, CA5B, CA1, CA8, CA2, CA12, CA7, CA14, CA3, CA13, CA5A, CA6, CA11, CA10 |
| Tissue | NA |
| Tissue Specificity | Expressed in the endothelium of the choriocapillaris in eyes (at protein level). Not expressed in the retinal epithelium at detectable levels. {ECO:0000269|PubMed:15563508}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZNC (X-ray 2.80A ) 3F7B (X-ray 2.05A ) 3F7U (X-ray 2.00A ) 3FW3 (X-ray 1.72A ) 5IPZ (X-ray 2.10A ) 5JN8 (X-ray 1.85A ) 5JN9 (X-ray 2.10A ) 5JNA (X-ray 2.00A ) 5JNC (X-ray 2.00A ) 5KU6 (X-ray 1.80A ) |
| DBSNP | rs1245199379 rs104894559 rs121434552 rs185942554 rs121434551 rs2229178 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15563508}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:7625839}. |
| Mouse PG classification | NA |
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