| Gene Information | |
|---|---|
| Gene Name | TARDBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 414 |
| Protein Names | TAR DNA-binding protein 43 (TDP-43) |
| Target Name | tar dna binding protein 43 |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000120948 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13148 |
| Gene Card | TARDBP |
| Uniprot ID | Q13148 |
| Pfam | PF00076; PF18694 |
| In ASD | yes |
| Allosteric Prediction | yes (0.305945943) |
| Ortholog in Animals | Alpaca_ TARDBP ( ortholog_one2one ) Alpaca_ TARDBP ( ortholog_one2many ) Dog_ TARDBP ( ortholog_one2one ) GuineaPig_ TARDBP ( ortholog_one2one ) Macaque_ TARDBP ( ortholog_one2one ) Mouse_ Tardbp ( ortholog_one2one ) Pig_ TARDBP ( ortholog_one2one ) Rat_ Tardbp ( ortholog_one2one ) Rabbit_ TARDBP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBMS2, PABPC1, PABPC3, RBM24, ELAVL4, ELAVL3, RBMS1, ELAVL2, PUF60, RBM34, RBM45, HNRNPR, SYNCRIP, PABPC1L, PABPC5, RBM14, PABPC1L2A, PABPC1L2B, SF3B4, RBM38, ELAVL1, RBMS3, PABPC4, PABPC4L |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.005405(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WF0 (NMR - ) 2CQG (NMR - ) 2N2C (NMR - ) 2N3X (NMR - ) 2N4G (NMR - ) 2N4H (NMR - ) 2N4P (NMR - ) 4BS2 (NMR - ) 4IUF (X-ray 2.75A ) 4Y00 (X-ray 3.00A ) 4Y0F (X-ray 2.65A ) 5MDI (X-ray 2.10A ) 5MRG (NMR - ) 5W50 (X-ray 1.40A ) 5W52 (EM 1.40A ) 5W7V (EM 3.80A ) 5WHN (X-ray 1.10A ) 5WHP (X-ray 1.00A ) 5WIA (X-ray 1.00A ) 5WIQ (X-ray 1.25A ) 5WKB (EM 1.00A ) 5WKD (X-ray 1.80A ) 5X4F (NMR - ) 6B1G (NMR - ) 6CF4 (EM 0.75A ) 6CFH (EM 1.50A ) 6N37 (EM 3.80A ) 6N3A (EM 3.30A ) 6N3B (EM 3.80A ) 6N3C (EM 3.30A ) 6T4B (X-ray 2.55A ) 7KWZ (EM 3.20A ) 7N9H (X-ray 2.20A ) 7PY2 (EM 2.60A ) |
| DBSNP | rs80356715 rs80356717 rs80356718 rs80356719 rs121908395 rs80356721 rs80356721 rs80356723 rs80356723 rs4884357 rs80356726 rs80356727 rs80356728 rs80356729 rs80356730 rs80356731 rs80356733 rs80356735 rs80356739 rs80356738 rs367543041 rs80356741 rs80356742 rs80356743 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17023659, ECO:0000269|PubMed:17481916, ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:28663553, ECO:0000269|PubMed:29438978}. Cytoplasm {ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:23398327, ECO:0000269|PubMed:30464263}. Cytoplasm, Stress granule {ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:23398327}. Mitochondrion {ECO:0000269|PubMed:28794432, ECO:0000269|PubMed:33031745}. Note=Continuously travels in and out of the nucleus (PubMed:18957508). Localizes to stress granules in response to oxidative stress (PubMed:19765185). A small subset localizes in mitochondria (PubMed:28794432). {ECO:0000269|PubMed:18957508, ECO:0000269|PubMed:19765185, ECO:0000269|PubMed:28794432}. |
| Mouse PG classification | LPG |
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