| Gene Information | |
|---|---|
| Gene Name | ADM |
| Organism | Homo sapiens (Human) |
| Gene Length | 185 |
| Protein Names | Pro-adrenomedullin [Cleaved into: Adrenomedullin (AM); Proadrenomedullin N-20 terminal peptide (ProAM N-terminal 20 peptide) (PAMP) (ProAM-N20)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000148926 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P35318 |
| Gene Card | ADM |
| Uniprot ID | P35318 |
| Pfam | PF00214 |
| In ASD | no |
| Allosteric Prediction | yes (0.335683701) |
| Ortholog in Animals | Alpaca_ ADM ( ortholog_one2one ) Dog_ ADM ( ortholog_one2one ) GuineaPig_ ADM ( ortholog_one2one ) Macaque_ ADM ( ortholog_one2one ) Mouse_ Adm ( ortholog_one2one ) Pig_ ADM ( ortholog_one2one ) Rat_ Adm ( ortholog_one2one ) Rabbit_ ADM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ADM2 |
| Tissue | NA |
| Tissue Specificity | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.157194(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FLY (NMR - ) 2L7S (NMR - ) 4RWF (X-ray 1.76A ) 5V6Y (X-ray 2.80A ) 6UUN (EM 3.00A ) 6UUS (EM 2.40A ) 6V2E (X-ray 1.83A ) 7VV0 (EM 3.50A ) |
| DBSNP | rs5005 rs2228573 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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