| Gene Information | |
|---|---|
| Gene Name | SLC22A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 554 |
| Protein Names | Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000175003 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O15245 |
| Gene Card | SLC22A1 |
| Uniprot ID | O15245 |
| Pfam | PF00083 |
| In ASD | no |
| Allosteric Prediction | yes (0.701366555) |
| Ortholog in Animals | Alpaca_ SLC22A1 ( ortholog_one2one ) Dog_ SLC22A1 ( ortholog_one2one ) Macaque_ SLC22A1 ( ortholog_one2one ) Mouse_ Slc22a1 ( ortholog_one2one ) Pig_ SLC22A1 ( ortholog_one2one ) Rat_ Slc22a1 ( ortholog_one2one ) Rabbit_ SLC22A1 ( ortholog_one2one ) |
| Ohnologs | SLC22A8, SLC22A11, SLC22A25, SLC22A6, SLC22A13 |
| Paralogs | SLC22A24, SLC22A12, SLC22A6, SVOP, SLC22A17, SLC22A7, SLC22A11, SLC22A23, SLC22A2, SLC22A25, SLC22A15, SLC22A9, SLC22A4, SLC22A5, SLC22A3, SLC22A16, SLC22A8, SVOPL, SLC22A31, SLC22A13, SLC22A14, SLC22A10 |
| Tissue | liver, brain |
| Tissue Specificity | Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269|PubMed:11388889, ECO:0000269|PubMed:9187257, ECO:0000269|PubMed:9260930}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34447885 rs2297373 rs12208357 rs35546288 rs55918055 rs683369 rs34104736 rs36103319 rs4646277 rs4646278 rs2282143 rs34205214 rs34130495 rs628031 rs72552763 rs35956182 rs34295611 rs34059508 rs35270274 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}. |
| Mouse PG classification | NA |
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