| Gene Information | |
|---|---|
| Gene Name | CA12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 354 |
| Protein Names | Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) |
| Target Name | carbonic anhydrase 12 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000074410 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O43570 |
| Gene Card | CA12 |
| Uniprot ID | O43570 |
| Pfam | PF00194 |
| In ASD | no |
| Allosteric Prediction | yes (0.025594368) |
| Ortholog in Animals | Alpaca_ CA12 ( ortholog_one2one ) Dog_ CA12 ( ortholog_one2one ) GuineaPig_ CA12 ( ortholog_one2one ) Macaque_ CA12 ( ortholog_one2one ) Mouse_ Car12 ( ortholog_one2one ) Pig_ CA12 ( ortholog_one2one ) Rat_ Ca12 ( ortholog_one2one ) Rabbit_ CA12 ( ortholog_one2one ) |
| Ohnologs | CA9, CA14 |
| Paralogs | CA9, CA5B, CA1, CA8, CA2, CA7, CA14, CA3, CA13, CA4, CA5A, CA6, CA11, CA10 |
| Tissue | kidney |
| Tissue Specificity | Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677). {ECO:0000269|PubMed:26911677}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1JCZ (X-ray 1.55A ) 1JD0 (X-ray 1.50A ) 4HT2 (X-ray 1.45A ) 4KP5 (X-ray 1.45A ) 4KP8 (X-ray 1.80A ) 4Q0L (X-ray 2.00A ) 4QJ0 (X-ray 1.55A ) 4QJO (X-ray 1.80A ) 4QJW (X-ray 1.55A ) 4WW8 (X-ray 1.42A ) 5LL5 (X-ray 1.42A ) 5LL9 (X-ray 1.45A ) 5LLO (X-ray 1.60A ) 5LLP (X-ray 1.48A ) 5MSA (X-ray 1.20A ) 5MSB (X-ray 1.30A ) 6G5L (X-ray 1.21A ) 6G7A (X-ray 1.42A ) 6QN0 (X-ray 1.89A ) 6QNG (X-ray 1.67A ) 6QNL (X-ray 1.53A ) 6R6Y (X-ray 1.38A ) 6R71 (X-ray 2.00A ) 6RPS (X-ray 2.79A ) 6T5P (X-ray 1.50A ) 6T5Q (X-ray 1.80A ) 7PUU (X-ray 1.51A ) 7PUV (X-ray 1.40A ) 7PUW (X-ray 1.42A ) |
| DBSNP | rs775067652 rs267606694 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000269|PubMed:26911677}. |
| Mouse PG classification | NA |
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